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Thursday 2 August 2012

CLOTTING FACTORS AND INHERITANCE

Clotting Factors
Name
Inheritance
t1/2

I
Fibrinogen
AR
2-4 days
II
Prothrombin
AR
3-4 days
III
Thromboplastin
AR

IV
Calcium
AR

V
Proaccelerin/Labile Factor
AR
36 hrs
VI
-
-
-
VII
Proconvertin/Stable Factor
AR
4-6 hrs
VIII
Anti-Hemophilic Globulin/ Anti-Hemophilic Factor A
X-Linked
8-12 hrs
IX
Christmas Factor/ Anti-Hemophilic Factor B/ Plasma Thromboplastic Component
X-linked
18-24 hrs
X
Stuart-Prower Factor
AR
40-60 hrs
XI
Plasma Thromboplastin Antecedent/
Anti-Hemophilic Factor C
AR
40-70 hrs
XII
Hageman factor/ Glass Factor
AR
60 hrs
XIII
Fibrin Stabilizing Factor/ Laki Lorand Factor
AR
11-14 days
HMW-K
High Molecular Weight- Kininogen/ Fitzgerald Factor
AR
150 hrs

Prekallikrein
AR
35 hrs

Vit K Dependent Clotting factors:- (Vit K helps in gamma-carboxylation of the Glutamate residues of the following factors, which takes place in LIVER)

  1. Factor II
  2. Factor VII
  3. Factor IX
  4. Factor X
  5. Protein C
  6. Protein S

1 comment:

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